Study of thiotepa and trastuzumab for breast cancer that spread to the lining of the brain and spinal cord
Part of Brain & nervous system, Cancer clinical trials.
This trial tests a combination of two drugs given through a special port in the head to treat HER2-positive breast cancer that has spread to the layer covering the brain and spinal cord (leptomeningeal metastasis). It aims to see if this treatment is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have HER2-positive breast cancer, confirmed by a biopsy or other lab tests
- You have been diagnosed with leptomeningeal metastasis (cancer spread to the lining of the brain and spinal cord)
- You already have or are able to get a small device called an Ommaya reservoir placed in your head to deliver the drugs
- You are between 18 and 75 years old
- Your overall health, blood counts, and organ function are good enough for treatment
- You are not pregnant, not breastfeeding, and willing to avoid pregnancy during the study and for 6 months after
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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