Sealing damaged lung parts in severe emphysema
Part of Lungs & breathing clinical trials.
This trial tests a new treatment called AeriSeal to seal off damaged parts of the lung in people with severe emphysema. It aims to help you breathe better by reducing the amount of air trapped in your lungs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 40 and 80 years old.
- You have completed a pulmonary rehab program in the past year and have not smoked for at least 8 weeks.
- You have severe emphysema that is unevenly spread (heterogeneous) and one lung lobe is very damaged (at least 50% destruction).
- You have a gap in the fissure (the natural division between lung lobes) that is 80% or more complete, and that gap is limited to three segments within the target lobe.
- You can walk between 150 and 450 meters in 6 minutes, and you have significant shortness of breath (mMRC score of 2 or more).
- Your lung function tests show severe obstruction (FEV1 between 15% and 45% of predicted, FEV1/FVC less than 0.7) and your lungs are overinflated (TLC at least 100% predicted, RV at least 175% predicted).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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