Personalized defibrillator plan for non-ischemic heart failure (SPANISH-1)
Part of Heart & circulation clinical trials.
This trial is testing a personalized approach to deciding who gets an implantable defibrillator (ICD) for people with heart failure due to dilated cardiomyopathy (not from blocked arteries). It aims to see if MRI scans and other factors can better match the device to those who need it most.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have dilated cardiomyopathy not caused by blocked arteries.
- You are 18 or older.
- You have been on the best possible heart failure medications for at least 3 months.
- You feel short of breath with some activity (NYHA class II or III).
- Your heart's pumping strength is 35% or less on an MRI.
- You have no history of dangerous fast heart rhythms or cardiac arrest.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at whether using a heart MRI (CMR) to guide where to place an implanted defibrillator (ICD) improves outcomes for people with a weakened heart muscle caused by non-ischemic dilated cardiomyopathy. It’s for adults who have low pumping strength and evidence of heart scarring on MRI.
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This study compares modern heart failure medications and implantable cardioverter-defibrillators (ICDs) to reduce the risk of sudden cardiac death in people with a specific type of heart muscle disease (non-ischemic cardiomyopathy) that is not caused by blocked arteries. It may help guide treatment decisions for those with a weakened heart and certain scarring on heart MRI.
This study looks at whether implantable defibrillators can reduce dangerous heart rhythms in people with non-ischemic cardiomyopathy (heart weakness not caused by blocked heart arteries), a heart scar, and very low pumping strength despite best treatment. It compares different approaches to choosing which patients should receive these devices.
This study is developing a digital tool to help people 70 and older with heart failure decide whether an ICD (a device that prevents dangerous heart rhythms) is right for them. Participants will help test and improve this tool.
This study uses an MRI scan of the heart to better identify which people with heart failure need a defibrillator along with a special pacemaker (cardiac resynchronization therapy). The scan may help doctors decide if the device could improve your heart's pumping and reduce risks.
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