MRI-guided heart defibrillator placement for non-ischemic weakened hearts
Part of Heart & circulation clinical trials.
This study looks at whether using a heart MRI (CMR) to guide where to place an implanted defibrillator (ICD) improves outcomes for people with a weakened heart muscle caused by non-ischemic dilated cardiomyopathy. It’s for adults who have low pumping strength and evidence of heart scarring on MRI.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 years or older and can sign consent to join the study
- You have non-ischemic dilated cardiomyopathy (not caused by a prior heart attack)
- Your MRI shows heart scarring (fibrosis) and your heart pumping strength (LVEF) is 35% or lower
- You can safely complete a heart MRI (no major MRI restrictions, no gadolinium allergy)
- You do not have severe kidney problems (eGFR/creatinine clearance must be at least 30 mL/min)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing a personalized approach to deciding who gets an implantable defibrillator (ICD) for people with heart failure due to dilated cardiomyopathy (not from blocked arteries). It aims to see if MRI scans and other factors can better match the device to those who need it most.
This study tests if doing a special heart procedure (catheter ablation) at the same time as implanting a defibrillator (ICD) can prevent dangerous heart rhythms better than the ICD alone. It is for people with a very weak heart pump due to blocked arteries who are getting a first-time ICD.
This trial tests whether using an MRI to help place a defibrillator (a device that corrects dangerous heart rhythms) works better than the usual method. It may help people with weak heart pumping after a heart attack.
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This study compares modern heart failure medications and implantable cardioverter-defibrillators (ICDs) to reduce the risk of sudden cardiac death in people with a specific type of heart muscle disease (non-ischemic cardiomyopathy) that is not caused by blocked arteries. It may help guide treatment decisions for those with a weakened heart and certain scarring on heart MRI.
This study looks at whether implantable defibrillators can reduce dangerous heart rhythms in people with non-ischemic cardiomyopathy (heart weakness not caused by blocked heart arteries), a heart scar, and very low pumping strength despite best treatment. It compares different approaches to choosing which patients should receive these devices.
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