ACTH for children with frequently relapsing nephrotic syndrome
Part of Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests if a hormone called ACTH can help children with nephrotic syndrome who have frequent relapses or need steroids to stay in remission. It aims to find a treatment that may reduce the need for steroids and prevent relapses.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 2 and 14 years old
- You have nephrotic syndrome that responds to steroids but comes back often or you need steroids to keep it controlled
- Your kidneys are working normally (eGFR at least 90)
- Your urine shows little to no protein for at least 3 days in a row when you start
- You have not used other immune-suppressing drugs in the past 3 months, and no rituximab or belimumab in the past 6 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests an injection (SG301) that targets a protein called CD38 to help children whose nephrotic syndrome keeps coming back or depends on steroids. The goal is to see if the treatment can reduce relapses and the need for steroids.
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This trial studies whether rituximab alone can help children with new-onset idiopathic nephrotic syndrome. It compares the treatment approach in order to see if it improves kidney recovery and reduces disease activity.
This study is looking for children newly diagnosed with idiopathic nephrotic syndrome (a kidney condition that causes swelling and protein in the urine) who have not yet been treated. Researchers will study their blood and genes to find better ways to predict how the disease will progress and which treatments might work best.
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