Telitacicept for children with frequently relapsing nephrotic syndrome
Treatments studied
Part of Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a new drug called telitacicept to help children whose nephrotic syndrome keeps coming back often or who need steroids to stay in remission. The goal is to see if it can keep urine protein levels low and reduce relapses.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 2 and 18 years old.
- You have nephrotic syndrome that responds to steroids but returns often (frequent relapses) or you need steroids to keep it controlled (steroid-dependent).
- Your kidneys are working well (estimated kidney function is at least 90).
- Your morning urine shows little to no protein for at least 3 days in a row before joining.
- You have not used certain strong immune-suppressing drugs like rituximab in the last 6 months, or others like tacrolimus, mycophenolate, cyclosporine, cyclophosphamide, or ACTH in the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests an injection (SG301) that targets a protein called CD38 to help children whose nephrotic syndrome keeps coming back or depends on steroids. The goal is to see if the treatment can reduce relapses and the need for steroids.
This trial tests if a hormone called ACTH can help children with nephrotic syndrome who have frequent relapses or need steroids to stay in remission. It aims to find a treatment that may reduce the need for steroids and prevent relapses.
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