Predicting cartilage damage and pain after knee injury or early arthritis
Part of Bones, joints & muscles, Injuries & trauma clinical trials.
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are under 70 years old.
- You have either: an ACL injury within the last year (with or without plans for surgery) OR early to moderate knee osteoarthritis (X-ray grades 1-3) OR you are a healthy volunteer without knee problems.
- Your BMI is 32 or lower.
- You can have an MRI scan (no pacemaker, no severe claustrophobia, and your thigh and calf fit the MRI coil).
- You have not had any previous knee surgery (except the planned ACL reconstruction for the ACL surgery group).
- You do not use cannabis, opioids, or other drugs (unless prescribed by your doctor).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether using vibration after an ACL injury helps predict or reduce the risk of developing post-traumatic osteoarthritis (wear-and-tear arthritis) later. It may help researchers learn which patients are more likely to develop arthritis after ACL reconstruction.
This trial studies ACL (knee ligament) injuries and how the tibia (shin bone) shifts, using MRI scans taken before surgery. It may help doctors better understand knee instability and improve how ACL injuries are evaluated and treated.
This study looks at how a specific knee bone alignment issue seen on MRI relates to how well ACL surgery works afterward. It may help doctors better predict outcomes after ACL reconstruction.
This study tests whether increasing your daily steps after ACL reconstruction can help prevent knee osteoarthritis. It involves walking more and tracking your activity over time.
This study tests pain management options after ACL reconstruction to reduce the need for strong painkillers. It may help you recover with fewer side effects and lower risk of opioid dependence.
This trial tests a faster MRI scan method to measure healing in the knee after an ACL (anterior cruciate ligament) tear and reconstruction. It may help researchers compare scan quality while participants go through standard rehab.
Hear when a new Anterior Cruciate Ligament Injuries trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.