Repeat catheter ablation for persistent atrial fibrillation: adding back-wall isolation to standard treatment
Part of Heart & circulation clinical trials.
If you have persistent atrial fibrillation that keeps coming back after a previous ablation, this study tests whether adding extra burns on the back wall of the heart's left upper chamber helps maintain normal rhythm better than just doing the standard vein isolation again. The goal is to see which approach reduces the chance of AF returning.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have symptoms from persistent atrial fibrillation (a type of irregular heartbeat that lasts more than 7 days).
- You have had at least one previous catheter ablation for AF, but no more than two, and only in the pulmonary veins (the veins that bring blood from your lungs to your heart).
- In the last 12 months, you have had at least one episode of AF lasting more than 7 days, and you have been electrically cardioverted (shocked to restore normal rhythm) at least once.
- Your persistent AF has lasted less than 3 years.
- You have taken at least one antiarrhythmic drug (medication to control heart rhythm).
- You have been on blood thinners (like warfarin or a DOAC) for at least 4 weeks before the procedure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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