Repeat ablation for persistent atrial fibrillation
Part of Heart & circulation clinical trials.
This study tests whether doing a second ablation (a procedure that uses heat or cold to destroy tiny areas of heart tissue that cause irregular beats) can help people with persistent atrial fibrillation (a continuous irregular heartbeat) that has come back after a first ablation. It aims to see if this repeat procedure safely reduces symptoms and improves heart rhythm.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have already had a procedure called pulmonary vein isolation (a type of ablation for irregular heartbeat).
- You have had at least two episodes of symptomatic persistent atrial fibrillation (continuous irregular heartbeat lasting more than a week) in the last year.
- You are older than 18 and expected to live for more than a year.
- You have not had prior ablation in other heart areas except certain limited ones (like the cavotricuspid isthmus, roof, dome, or posterior wall).
- You do not have atypical atrial flutter (a separate rhythm problem) or atrial fibrillation caused by a temporary issue.
- You have not had a recent heart attack, heart surgery, or stroke, and you do not have severe kidney failure or active substance/alcohol abuse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
If you have persistent atrial fibrillation that keeps coming back after a previous ablation, this study tests whether adding extra burns on the back wall of the heart's left upper chamber helps maintain normal rhythm better than just doing the standard vein isolation again. The goal is to see which approach reduces the chance of AF returning.
This study tests a new way to find and treat the specific areas in the heart that cause atrial fibrillation to come back. It aims to improve the success of a repeat ablation procedure for people whose previous pulmonary vein isolation did not stop the irregular heartbeats.
This study compares two types of ablation (a procedure that uses energy to fix irregular heartbeats) for people with persistent atrial fibrillation. It tests whether adding extra treatment to the back of the heart's left upper chamber helps improve outcomes compared to standard treatment alone.
This trial tests a newer type of energy (pulsed field ablation) against the standard heat-based method (radiofrequency) for people who have already had one ablation and now have atrial fibrillation again. The goal is to see which works better for keeping your heart in a normal rhythm.
This study compares two extra ablation procedures done along with standard pulmonary vein isolation in people with persistent atrial fibrillation. Both aim to stop abnormal electrical signals that drive atrial fibrillation, and the study will see which approach is safer and more effective.
This trial compares different techniques for a second heart ablation procedure in people with atrial fibrillation (AFib) who have already had one ablation. It aims to find the best approach to stop AFib from coming back.
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