Gene therapy for chronic back pain from disc degeneration
Part of Bones, joints & muscles clinical trials.
This trial tests an investigational gene therapy injected into the spine for people with long-term low back pain caused by degenerative disc disease. It aims to see if the treatment is safe and tolerable, and whether it can reduce pain and improve function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 22 and 70 years old.
- You have had chronic low back pain for at least 6 months, and your back pain is noticeably worse than leg pain.
- Your pain and disability scores are within a moderate-to-severe range (pain 40–90 on a 0–100 scale).
- You have not gotten enough relief from at least one pain medication and physical therapy for at least 6 months.
- You have a diagnosis of disc degeneration between the L1 and S1 vertebrae confirmed by MRI, with a Pfirrmann score of 3–7 (moderate to severe).
- You have a body mass index (BMI) between 15 and 30 and agree to use birth control if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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