Stem cell therapy for severe traumatic brain injury
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This trial tests whether a single infusion of stem cells from donated umbilical cord tissue can help calm inflammation in the brain after severe traumatic brain injury. It is for patients aged 18–50 who need brain pressure monitoring and are not responding to verbal commands 5 days after sedation is stopped.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 50 years old.
- You have had a severe traumatic brain injury with a Glasgow Coma Scale score below 12 in the first 48 hours.
- A brain scan shows traumatic injury and you need a monitor to measure pressure inside your skull.
- You are not able to follow commands 5 days after stopping sedation, and your care team has not decided to stop active treatments within 10 days after sedation is stopped.
- You do not have other major injuries (score below 2 on a body injury scale).
- You do not have any metal implants or devices that would prevent you from having an MRI or PET-MRI scan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early study tests whether an intravenous (through a vein) stem cell treatment made from donated umbilical cord tissue is safe for people with traumatic brain injury. It focuses mainly on side effects and safety, and only includes participants who meet several health and pregnancy-related safety checks.
This study looks at the safety and outcomes of MUSE stem cell therapy for people with traumatic brain injury. If you have had a TBI at least 6 months ago and are planning to receive MUSE therapy outside the U.S., you may be able to join and help researchers learn more.
This study follows people who receive intranasal stem cell or exosome therapy (tiny packages from special cells) for brain or neurological conditions like stroke, brain injury, or cerebral palsy. Researchers track how well the treatment works by measuring inflammation markers in the blood and monitoring clinical improvements over time.
This study tests whether a treatment made from donor stem cells (called mesenchymal stromal cells) can help people recover from a severe traumatic brain injury. The cells are given through a vein within 48 hours of the injury.
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