Brain activity and memory in treatment-resistant depression
Part of Mental health clinical trials.
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have a current diagnosis of major depressive disorder that is moderate to severe.
- You have tried at least two antidepressants for this episode without success (or couldn't tolerate them).
- You are fluent in English and can give informed consent.
- You do not have bipolar disorder, psychosis, or a history of seizures or other conditions that would make MRI or rTMS unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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