Clin2
NCT06178159Possibly a fitRecruiting

New drug combo before surgery for HER2-positive breast cancer

Breast Cancer

Treatments studied

Part of Cancer, Skin clinical trials.

This trial tests a new combination of drugs (DV plus pertuzumab, with or without toripalimab) given before surgery for HER2-positive breast cancer. The goal is to see if this treatment can shrink the tumor and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must have HER2-positive breast cancer (confirmed by a lab test).
  • Your tumor must be larger than 2 centimeters and have not spread to other parts of the body.
  • You cannot have had any previous treatment for breast cancer (like chemotherapy or targeted therapy).
  • You must be healthy enough to have surgery after the study treatment.
  • You must have good heart, kidney, and liver function.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06389006Recruiting· Phase 2
Combination therapy before surgery for HER2-low, hormone-positive breast cancer

This trial tests a combination of two drugs (disitamab vedotin and toripalimab) followed by chemotherapy before surgery for people with a specific type of breast cancer that is hormone receptor-positive and HER2-low. The goal is to see if this treatment can shrink the tumor and improve outcomes.

Shanghai, Fudan University Shanghai Cancer Center
NCT06642545Recruiting· Phase 2
New targeted drug combo for HER2-low breast cancer

This trial tests a new combination of targeted drugs (Disitamab Vedotin and RC148) against a standard chemotherapy (Abraxane) with or without an immunotherapy drug (Toripalimab) for advanced breast cancer that is HER2-low and hormone receptor-negative. The goal is to see if the new combination works better at shrinking tumors and slowing cancer growth.

Beijing, Beijing Municipality
NCT06227117Recruiting· Phase 2
Study of DV and Toripalimab before surgery for HER2-low breast cancer

This trial tests a combination of two drugs (DV and Toripalimab) with chemotherapy before surgery for a specific type of breast cancer (HER2-low, HR-negative) that has not spread too far. The goal is to see if this approach can shrink the tumor and improve outcomes.

Changsha, Hunan
NCT07246317Not yet recruiting· Phase 2
Targeted therapy before surgery for HER2-positive breast cancer

This trial tests a combination of targeted drugs and chemotherapy before surgery for HER2-positive breast cancer. It aims to see if this approach can shrink or eliminate the tumor, making surgery more effective.

Guangzhou, Guangdong
NCT07528898Not yet recruiting· Phase 2
Two-drug treatment before surgery for HER2-positive breast cancer

This study tests whether giving two drugs (SHR-A1811 and pertuzumab) before surgery can shrink HER2-positive breast cancer tumors. It aims to see if this combination improves treatment outcomes for patients with stage II or III disease.

Shijiazhuang, Hebei
NCT07527806Not yet recruiting· Phase 2
Personalized pre-surgery treatment for HER2-positive breast cancer

This trial tests different combinations of targeted therapy and chemotherapy before surgery for HER2-positive breast cancer. It uses a special PET scan to see how well the treatment is working and to help choose the best treatment plan for each person.

Hear when a new Breast cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.