Combination therapy before surgery for HER2-low, hormone-positive breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a combination of two drugs (disitamab vedotin and toripalimab) followed by chemotherapy before surgery for people with a specific type of breast cancer that is hormone receptor-positive and HER2-low. The goal is to see if this treatment can shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have HER2-low breast cancer (IHC 1+ or IHC 2+ without gene amplification).
- Your cancer is hormone receptor-positive (at least 1% of cells have estrogen or progesterone receptors).
- Your tumor is at least 2 cm in size and has spread to 1-3 lymph nodes, or is larger than 5 cm with or without lymph node involvement.
- You have not had any prior chemotherapy, hormone therapy, or targeted therapy for breast cancer.
- You are able to undergo surgery to remove the breast cancer after the study treatment.
- You are 18 or older, in good overall health, and willing to follow the study plan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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