Testing a new diagnostic test for heart rhythm disorders
Part of Heart & circulation clinical trials.
This study is evaluating a new diagnostic test for Calcium Release Deficiency Syndrome (CRDS) and related heart rhythm disorders. It aims to find out if this test can accurately identify patients with these conditions, which could lead to better diagnosis and treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have one of the following: a confirmed RyR2 gene variant that causes CRDS, or a diagnosis of CPVT, or have survived an unexplained cardiac arrest with genetic testing, or be undergoing an electrophysiology study for SVT.
- If you have CPVT, you must meet the clinical criteria for CPVT and have a specific type of RyR2 or CASQ2 gene variant.
- If you survived an unexplained cardiac arrest, your arrest must remain unexplained after standard tests, and you must have had genetic testing including RyR2.
- You cannot be on certain medications: a QT-prolonging medication (except flecainide) during the test for some groups, or class I or III anti-arrhythmic drugs for controls.
- You must be able to provide informed consent.
- If you are a control (SVT), you must not have certain other heart conditions like ventricular cardiomyopathy or long QT syndrome.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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