Revumenib for leukemia with HOX gene changes
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests an oral drug called revumenib (a menin inhibitor) for patients with acute leukemia that has returned or not responded to treatment, and whose leukemia has a specific HOX gene change. Revumenib aims to stop cancer growth by blocking a protein that helps leukemia cells survive.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 12 years old and weigh at least 88 pounds (40 kg).
- Your leukemia must have come back after treatment or not responded to previous therapy.
- Your leukemia must have a change in certain genes that turn on HOX (like KMT2A, NPM1, or others).
- Your white blood cell count must be below 25,000 before starting the trial (medication can be given to lower it first if needed).
- You must have fairly normal heart, liver, and kidney function, and be willing to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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