Blood pressure medicines and kidney health in septic shock
Treatments studied
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether different blood pressure medicines protect kidney function better in people with septic shock (a severe infection that causes low blood pressure). It compares norepinephrine (the standard treatment) with other options to see which is best for the kidneys.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are in the ICU and it's been less than 48 hours since you were admitted.
- You have a suspected or confirmed infection that is causing your body to fight it (sepsis).
- Your organs are showing signs of stress from the infection (a score of 2 or more on the SOFA test).
- You are receiving only norepinephrine, a medicine to raise blood pressure, at a certain dose.
- Your lactate level (a sign of illness) was above 2 mmol/L at some point.
- You do not have advanced kidney disease (stage 4 or 5), certain heart problems, or other conditions listed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two medicines—norepinephrine and angiotensin II—to see which one works better at raising blood pressure in people with septic shock (a severe infection that causes dangerously low blood pressure). It aims to find out which approach helps patients recover better.
This study tests whether giving certain fluids and a blood-pressure-raising medicine together early can help prevent kidney damage (acute kidney injury) in people with septic shock. If you are in intensive care with septic shock, this treatment might protect your kidneys.
This trial tests whether giving a second medicine called vasopressin early (along with norepinephrine) helps people with sepsis and low blood pressure better than waiting to use vasopressin only if norepinephrine doesn't work. It may improve blood pressure control and reduce the need for strong medicines.
This trial tests whether adding vasopressin (a hormone that narrows blood vessels) to usual care can improve recovery in patients with septic shock (a severe infection causing very low blood pressure). If you are already on a strong blood pressure medication, this study may help stabilize your condition.
This trial tests a drug called angiotensin II for people in the emergency room who need a specific dose of norepinephrine (a medicine to raise blood pressure) and are also getting antibiotics. The goal is to see if giving angiotensin II early can help stabilize blood pressure.
This trial tests whether giving a medicine called norepinephrine early and adjusting the dose quickly can help people with sepsis who have very low blood pressure. It is for adults who are diagnosed within the last 3 hours and who have not already received this medicine.
Hear when a new Septic Shock trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.