Blood pressure medicines and kidney health in septic shock
Treatments studied
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether different blood pressure medicines protect kidney function better in people with septic shock (a severe infection that causes low blood pressure). It compares norepinephrine (the standard treatment) with other options to see which is best for the kidneys.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are in the ICU and it's been less than 48 hours since you were admitted.
- You have a suspected or confirmed infection that is causing your body to fight it (sepsis).
- Your organs are showing signs of stress from the infection (a score of 2 or more on the SOFA test).
- You are receiving only norepinephrine, a medicine to raise blood pressure, at a certain dose.
- Your lactate level (a sign of illness) was above 2 mmol/L at some point.
- You do not have advanced kidney disease (stage 4 or 5), certain heart problems, or other conditions listed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests different combinations of blood pressure medicines given to patients on a breathing machine who have septic shock. The goal is to find the best dose of a second medicine when norepinephrine alone isn't enough.
This study tests two blood pressure-raising medicines, norepinephrine and angiotensin-II, in people with septic shock. It aims to see which one works better to improve blood flow and oxygen delivery to organs.
This trial tests whether giving fluids and norepinephrine together early can prevent kidney injury in people with septic shock. If you are in the ICU or ER with septic shock, this treatment might help protect your kidneys.
This trial examines how the renin-angiotensin-aldosterone system (a hormone system that helps control blood pressure) changes in patients with septic shock, compared to those with sepsis without shock, cardiogenic shock, and healthy volunteers. The goal is to better understand these changes and possibly improve treatment.
This trial tests whether giving a second medicine called vasopressin early (along with norepinephrine) helps people with sepsis and low blood pressure better than waiting to use vasopressin only if norepinephrine doesn't work. It may improve blood pressure control and reduce the need for strong medicines.
This trial tests whether adding vasopressin (a drug that helps raise blood pressure) to standard treatment can help people with septic shock. It is for adults who already need a high dose of another blood pressure medicine called noradrenaline.
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