Treating sepsis with norepinephrine plus early vasopressin
Part of Hormones & metabolism, Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether giving a second medicine called vasopressin early (along with norepinephrine) helps people with sepsis and low blood pressure better than waiting to use vasopressin only if norepinephrine doesn't work. It may improve blood pressure control and reduce the need for strong medicines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed or suspected infection (like sepsis) and have had low blood pressure requiring medicine for at least 1 hour.
- You are expected to be admitted to the ICU within the next 12 hours.
- Your doctor has given you enough fluids (intravenous fluids) to help with low blood pressure.
- You are currently on a medicine called norepinephrine at a specific dose (between 0.05 and 0.25 mcg/kg/min) for at least 1 hour but no more than 24 hours.
- You are not on dialysis for kidney failure or expected to need dialysis in the next 24 hours.
- You are not using any other blood pressure medicines besides norepinephrine right now.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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