Comparing norepinephrine and angiotensin-II for septic shock
Treatments studied
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests two blood pressure-raising medicines, norepinephrine and angiotensin-II, in people with septic shock. It aims to see which one works better to improve blood flow and oxygen delivery to organs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older with a serious infection that has caused dangerously low blood pressure.
- You are already receiving a medicine like norepinephrine to keep your blood pressure up, but may need more support.
- You can start the study medicine within 24 hours of needing a certain dose and within 48 hours of arriving at the hospital.
- You are not pregnant, not a prisoner, and do not have certain conditions like a very low white blood cell count or recent bone marrow transplant.
- You do not have liver cirrhosis that is moderately severe or worse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a drug called angiotensin II for people in the emergency room who need a specific dose of norepinephrine (a medicine to raise blood pressure) and are also getting antibiotics. The goal is to see if giving angiotensin II early can help stabilize blood pressure.
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This trial examines how the renin-angiotensin-aldosterone system (a hormone system that helps control blood pressure) changes in patients with septic shock, compared to those with sepsis without shock, cardiogenic shock, and healthy volunteers. The goal is to better understand these changes and possibly improve treatment.
This trial tests whether giving a medicine called norepinephrine early and adjusting the dose quickly can help people with sepsis who have very low blood pressure. It is for adults who are diagnosed within the last 3 hours and who have not already received this medicine.
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