Comparing two blood pressure medicines for septic shock
Treatments studied
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study compares two medicines—norepinephrine and angiotensin II—to see which one works better at raising blood pressure in people with septic shock (a severe infection that causes dangerously low blood pressure). It aims to find out which approach helps patients recover better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and have septic shock (a severe infection that causes dangerously low blood pressure).
- You are currently receiving a medicine like norepinephrine or phenylephrine (with or without other blood pressure support medicines) to maintain your blood pressure.
- You are on a moderate dose of norepinephrine (between 0.1 and 0.5 mcg/kg/min) to keep your blood pressure at a target level.
- You can be enrolled and consent within 24 hours of reaching the required medicine dose, and within 48 hours of arriving at the hospital.
- You are not a prisoner and not pregnant.
- You have not had a recent bone marrow transplant and do not have a very low white blood cell count (<1,000 cells/μL) or low monocyte count (<200 cells/μL).
- You are not expected to have urgent surgery and you are not planning to stop aggressive treatment, including blood pressure support.
- You do not have significant liver cirrhosis (a severe liver condition).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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