Vericiguat for chest pain from small vessel heart disease
Treatments studied
Part of Pain clinical trials.
This study tests whether a medication called vericiguat can improve chest pain caused by problems in the tiny blood vessels of the heart (not by large blockages). You may be a candidate if you have stable chest pain, are 40–75, and have had tests showing your heart's small vessels aren't working well.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have stable chest pain that comes on regularly.
- You are between 40 and 75 years old.
- A recent heart test (CT scan or angiogram) within the last 6 months showed no major blockages in your heart arteries.
- A special MRI of your heart shows that blood flow to the heart muscle is lower than normal.
- You are not taking certain other medications (like long-acting nitrates or drugs for erectile dysfunction), and your blood pressure is not too low.
- For women: you are not pregnant or breastfeeding, and you agree to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests a medicine called vericiguat (a pill) to see if it can improve the heart's shape and function in people with heart failure and a weakened pump. You would keep taking your usual heart medications plus the study drug.
This trial tests whether starting the medication vericiguat soon after a heart attack can help people whose hearts are weakened (ejection fraction 45% or lower) and who developed heart failure. Vericiguat is an oral medicine that may reduce strain on the heart and improve outcomes when given early.
This trial tests whether adding vericiguat to your usual heart failure medicines helps reduce pressure in your lungs and improve symptoms. You will have a CardioMEMS sensor already implanted to monitor your heart, and the study will use its readings to guide your care.
This trial tests whether the drug vericiguat, taken before and after heart surgery, can help protect the heart and reduce the risk of heart failure. It may help people who have heart problems going into surgery.
This study tests whether the drug vericiguat helps people with heart failure after a heart attack. The trial looks at people whose heart pumping is weak and who have symptoms despite standard treatment.
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