Quizartinib plus chemo for children with FLT3-ITD AML
Treatments studied
Part of Cancer clinical trials.
This study adds a targeted drug called quizartinib to standard chemotherapy for children with a certain type of acute myeloid leukemia (AML) that has a FLT3-ITD gene change. The goal is to see if this combination is safe and effective for treating newly diagnosed patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be enrolled in the main CHIP-AML22/Master study first.
- The leukemia cells must have a FLT3-ITD mutation and no NPM1 mutation (these are special gene changes).
- Your child must be between 1 month and 18 years old at diagnosis.
- Your child should be well enough to be out of bed and active more than half of the day.
- Your child's kidneys, liver, and heart must be working well enough based on blood tests and heart checks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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