Carvedilol to prevent liver complications in cirrhosis
Part of Digestive system clinical trials.
This trial tests if the drug carvedilol can prevent liver-related emergencies or death in people with cirrhosis and high blood pressure in the liver. It may help those who are stable right now but at risk for a sudden worsening.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older
- You have cirrhosis caused by hepatitis B/C, alcohol, or metabolic syndrome (with BMI under 30)
- A liver scan (FibroScan) in the last year showed a stiffness score of 25 kPa or higher
- You do not have large varices or varices with red spots in your esophagus
- Your liver function (Child-Pugh score) is A5 to B8
- You do not already take diuretics or lactulose for fluid buildup or come from certain conditions like very low heart rate or kidney disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
This trial tests whether a medicine called carvedilol can lower high blood pressure in the liver veins of people with cirrhosis. It uses a special ultrasound probe to measure the pressure before and after taking the medicine.
This trial tests whether adding metformin to carvedilol (a standard drug) lowers liver pressure more than carvedilol alone in people with cirrhosis who have had variceal bleeding. The goal is to prevent future bleeding.
This trial tests whether adding a statin (simvastatin) to the usual heart medication carvedilol helps people with both cirrhosis and a related heart problem live longer and avoid serious liver complications.
This trial is for people with liver cirrhosis who already take carvedilol for portal hypertension (high blood pressure in the liver's main vein). It tests whether adding alverine helps lower that pressure more effectively.
This study tests a medicine called carvedilol (a non-selective beta-blocker) to see if it can prevent complications in people with advanced chronic liver disease who are at high risk but haven't had serious problems like bleeding yet.
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