Metformin for reducing liver pressure in cirrhosis
Treatments studied
Part of Digestive system clinical trials.
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You have been diagnosed with cirrhosis (liver scarring) and have high liver pressure.
- You are currently taking carvedilol (a blood pressure medication) for at least one month.
- You do not have active liver cancer with a tumor larger than 3 cm or more than 3 tumors.
- You have not needed a procedure to drain fluid from your belly in the last 6 months.
- You are not taking metformin currently or have stopped it for at least 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a medicine called carvedilol can lower high blood pressure in the liver veins of people with cirrhosis. It uses a special ultrasound probe to measure the pressure before and after taking the medicine.
This study tests a new way to measure if a type of blood pressure medicine called non-selective beta-blockers (NSBBs) is helping patients with cirrhosis. It uses a thin, flexible tube with a camera (endoscope) to measure pressures in the liver and a nearby vein. If you have cirrhosis with high pressure in the portal vein but haven't started NSBBs yet, this study may help your doctor decide if the medicine is working for you.
This study is checking if it is safe for people with cirrhosis (liver scarring) to stop taking a certain blood pressure medicine (non-selective beta blockers) if their main liver problem is under control. If you've had varices or bleeding in the past and your liver is now stable, this trial will see if you can safely stop the medicine.
This study is testing ways to prevent and treat liver scarring (fibrosis) caused by a condition called MAFLD, which is a buildup of fat in the liver. If you have this condition and some liver scarring, this trial may offer a chance to help manage it.
This study tests whether the drug rosuvastatin, a cholesterol-lowering medicine, can improve liver health in people with cirrhosis. If you have compensated cirrhosis (no recent serious liver problems), you might be able to join.
This trial tests two heart medications, carvedilol and empagliflozin, to see if they improve heart function in people with cirrhosis (liver scarring). It might help those who have early signs of heart stiffness but normal pumping strength.
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