Metformin for reducing liver pressure in cirrhosis
Treatments studied
Part of Digestive system clinical trials.
This trial tests if metformin can lower the pressure in the liver's blood vessels (portal hypertension) in people with cirrhosis. The goal is to see if it can help reduce complications like swelling or bleeding.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You have been diagnosed with cirrhosis (liver scarring) and have high liver pressure.
- You are currently taking carvedilol (a blood pressure medication) for at least one month.
- You do not have active liver cancer with a tumor larger than 3 cm or more than 3 tumors.
- You have not needed a procedure to drain fluid from your belly in the last 6 months.
- You are not taking metformin currently or have stopped it for at least 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a medicine called carvedilol can lower high blood pressure in the liver veins of people with cirrhosis. It uses a special ultrasound probe to measure the pressure before and after taking the medicine.
This study tests a new way to measure if a type of blood pressure medicine called non-selective beta-blockers (NSBBs) is helping patients with cirrhosis. It uses a thin, flexible tube with a camera (endoscope) to measure pressures in the liver and a nearby vein. If you have cirrhosis with high pressure in the portal vein but haven't started NSBBs yet, this study may help your doctor decide if the medicine is working for you.
This study is checking if it is safe for people with cirrhosis (liver scarring) to stop taking a certain blood pressure medicine (non-selective beta blockers) if their main liver problem is under control. If you've had varices or bleeding in the past and your liver is now stable, this trial will see if you can safely stop the medicine.
This study tests strategies to prevent cirrhosis in people with metabolic fatty liver disease and early to moderate liver scarring. It aims to find better ways to stop liver damage from getting worse.
This study tests whether a blood pressure medication called propranolol can help patients with advanced cirrhosis (severe liver scarring) who have developed complications like fluid buildup, bleeding, or confusion. The goal is to see if it improves survival and slows disease progression.
This trial is for people with liver cirrhosis who have high blood pressure in the vein that carries blood to the liver (portal hypertension). It uses a special ultrasound with contrast to learn more about the condition.
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