Nicotinamide Riboside for Moyamoya in Smooth Muscle Dysfunction
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a vitamin B3 supplement called nicotinamide riboside (NR) to see if it can help people with Smooth Muscle Dysfunction Syndrome (SMDS) who have a specific gene mutation. The goal is to improve blood flow problems in the brain (moyamoya-like disease) caused by the condition.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a diagnosis of Smooth Muscle Dysfunction Syndrome (SMDS) with a specific change in the ACTA2 gene that affects arginine 179.
- You cannot have had surgery to replace a damaged part of your aorta with an artificial graft.
- You must not be allergic to niacin (vitamin B3) or nicotinamide riboside (a form of vitamin B3).
- You must not have taken niacin or nicotinamide riboside supplements in the last 8 weeks.
- You cannot be enrolled in any other research trial that tests a different treatment or intervention.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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