How SGLT2 inhibitors work in the kidneys for type 2 diabetes
Treatments studied
Part of Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests how a drug called canagliflozin (an SGLT2 inhibitor) affects kidney function in people with type 2 diabetes. It involves two kidney biopsies to see how the drug works inside your kidneys, aiming to better protect kidney health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have had type 2 diabetes for at least 3 years.
- Your kidney function (eGFR) is between 45 and 90 ml/min, which is a mild to moderate decline.
- You have not taken any SGLT2 inhibitor (like canagliflozin, dapagliflozin, empagliflozin) before.
- You are not pregnant or planning pregnancy in the next 3 years, and you agree to use effective birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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