Clin2
NCT06377397Possibly a fitNot yet recruiting

Antibiotics only when symptoms appear for preterm babies

SepsisPROM, Preterm (Pregnancy)Early-Onset Neonatal SepsisPreterm Premature Rupture of MembranePreterm Birth

Part of Genetic & congenital, Infections, Women’s health & pregnancy clinical trials.

This trial compares giving antibiotics to all preterm babies at risk of infection versus giving them only if symptoms develop. It aims to find out if waiting is safer and reduces unnecessary antibiotic use.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
1,500 people
Ages
birth to 4 hours
Study type
Interventional

Who can take part

  • Your baby was born between 26 and 34 weeks of pregnancy
  • Your baby is at least 4 hours old
  • Your baby's water broke more than 18 hours before birth
  • Your baby has no signs of infection at 4 hours of age (like breathing trouble, seizures, or feeding issues)
  • Your baby has not already received antibiotics
  • Your baby is not part of a multiple birth (twins, triplets, etc.)

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06100614Recruiting
Using a blood test to reduce antibiotics in preterm newborns

This study checks if a blood test (presepsin) can help doctors safely stop antibiotics earlier in preterm babies at moderate risk of infection. The goal is to reduce unnecessary antibiotic use.

Amsterdam, North Holland
NCT06396078Recruiting· Phase 4
Antibiotics for Early Water Breaking Before Delivery

This study tests whether giving antibiotics to pregnant people with early water breaking (PPROM) before delivery improves outcomes. It aims to prevent infections and protect both parent and baby while waiting for delivery.

Columbus, Ohio
NCT04047849Recruiting· Phase 4
Antibiotics for early water breaking before 23 weeks

This trial studies whether taking antibiotics can help in pregnancies where the “water” broke early (before 23 weeks) but you don’t have a fever. It aims to reduce complications while keeping both mother and baby as safe as possible.

Baton Rouge, Louisiana
NCT07813767Recruiting· Phase 3
Early antibiotic treatment guided by a blood test to prevent severe infection

This study tests whether giving an early antibiotic (meropenem) based on a new blood test (PSP) can prevent serious infections (sepsis) in people who come to the emergency department with signs of infection. The goal is to find out if this approach helps them get better faster and avoid more severe illness.

Athens, Attica
NCT07484633Not yet recruiting· Phase 4
Comparing antibiotic infusion methods for children with sepsis

This study compares two ways of giving antibiotics to children with sepsis: the usual short infusions versus longer or continuous infusions. The goal is to see if one approach works better or is safer.

Budapest
NCT06572761Not yet recruiting· Phase 3
Antibiotics for early threatened labor to protect baby health

This trial tests whether giving a combination of antibiotics to women with threatened very early labor (before 24 weeks) can reduce the chances of the baby being born too early and having health problems. It aims to help improve outcomes for both mother and baby.

Poissy

Hear when a new Sepsis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.