Study of patritumab deruxtecan for NRG1 fusion-positive tumors
Treatments studied
Part of Cancer clinical trials.
This trial tests a new drug called patritumab deruxtecan for people with advanced solid tumors that have an NRG1 fusion. The drug targets a protein called HER3 on cancer cells and may help shrink tumors or slow their growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older.
- Your cancer must be advanced (spread or cannot be removed by surgery) and you must have a specific gene change called an NRG1 fusion, confirmed by a tumor or blood test.
- You need at least one tumor that can be measured on a scan.
- You must be willing to provide a new or recent tumor tissue sample for testing.
- You must have good overall health (able to do daily activities) and adequate organ function (like bone marrow, kidneys, and liver).
- You cannot have a history of certain lung conditions, active brain metastases, or other active cancers in the last 3 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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