Cognitive training and medication for depression
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests whether a combination of cognitive training (brain exercises) and a medication (guanfacine or sertraline) can improve thinking skills in people with depression. It involves MRI scans and computer tasks to understand how your brain responds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- You have been diagnosed with major depression (not bipolar, PTSD, OCD, ADHD, or an eating disorder).
- You have had symptoms of depression (like loss of interest or feeling down) most days for at least the past two weeks.
- You are fluent in English and can read and write in English.
- You are willing to have an MRI brain scan and complete computer tests of thinking and memory.
- You are not pregnant, breastfeeding, or planning to become pregnant, and you agree to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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