Clin2
NCT06418594Possibly a fitRecruiting

Drug combo for HER2-negative breast cancer brain metastasis

HER2-negative Breast Cancer Brain Metastases

Treatments studied

Part of Brain & nervous system, Cancer clinical trials.

This trial tests a combination of two drugs (adebrelimab and apatinib) plus chemotherapy for women with HER2-negative breast cancer that has spread to the brain. It aims to see if this treatment can help shrink or control brain tumors.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are female and at least 18 years old.
  • Your breast cancer is HER2-negative (a certain protein tested low or absent).
  • You have brain metastases that are new or have grown after previous treatment.
  • Your general health is good enough to be up and about for at least half the day (performance status 0–2).
  • You can swallow pills and your major organs (heart, liver, kidneys) are working fairly well.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06839560Recruiting· Phase 2
Immunotherapy plus chemotherapy and radiation for advanced breast cancer with brain metastases

This trial tests a combination of a PD-L1 inhibitor with a low-dose chemotherapy regimen and either immediate or delayed radiation therapy for people with HER2-negative breast cancer that has spread to the brain. The goal is to see if this approach helps shrink brain tumors and improve outcomes.

Beijing, Beijing Municipality
NCT06015113Not yet recruiting
Targeted drug combination for HER2-positive breast cancer with brain metastases

This trial tests a new combination of targeted drugs for HER2-positive breast cancer that has spread to the brain. You might be able to join if you have brain metastases and are either newly diagnosed or have had prior brain radiation.

Xi'an, Shaanxi
NCT06975475Not yet recruiting· Phase 2
Combination treatment for HER2-positive breast cancer that has spread to the brain

This trial tests two new drugs, SHR-A1811 and THPy, for women with HER2-positive advanced breast cancer that has spread to the brain. It aims to see if this combination can shrink brain tumors and improve outcomes for patients who have not yet had systemic treatment for advanced disease.

NCT05769010Recruiting· Phase 2
HER2-positive or low breast cancer brain metastasis drug study

This Phase 2 study tests SHR-A1811 in people with HER2-positive (or HER2-low) advanced breast cancer that has spread to the brain. It aims to shrink brain tumors and control the cancer in the brain, especially when there was no need for urgent local treatment like radiation or surgery.

Zhengzhou, Henan
NCT07177950Not yet recruiting· Phase 1/Phase 2
New targeted therapy for HER2-positive breast cancer with brain spread

This study is testing a new targeted therapy for people with HER2-positive breast cancer that has spread to the brain. It aims to see if the drug can help shrink brain tumors and improve outcomes for two groups: those with cancer in the fluid around the brain and those without.

NCT06718933Recruiting· Phase 1/Phase 2
Study of a drug combination for breast cancer that spread to the brain

This trial tests whether a combination of three drugs (SHR-A1811, pyrotinib, and bevacizumab) can help people with advanced breast cancer that has spread to the brain. It aims to shrink brain tumors and stop them from growing.

Shanghai, Shanghai Municipality

Hear when a new HER2-negative Breast Cancer Brain Metastases trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.