Duloxetine to reduce opioid use after knee replacement
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 50 years old or older.
- You have knee osteoarthritis and are scheduled for a total knee replacement on one knee.
- Your general health is good (classified as ASA I, II, or III).
- You are not taking certain antidepressants, strong painkillers, or other medications that could interact with the study drug.
- You do not have severe kidney disease, liver disease, uncontrolled glaucoma, or uncontrolled high blood pressure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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