Duloxetine and exercise for knee arthritis in veterans
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether combining the medication duloxetine with a supervised exercise program can improve function and reduce pain in veterans with knee osteoarthritis who also have some depressive symptoms. It aims to see if this combination works better than either treatment alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a veteran aged 40 or older.
- You have knee osteoarthritis diagnosed by a doctor.
- You have mild to severe depressive symptoms, based on a questionnaire.
- You are not currently taking antidepressants, opioids, benzodiazepines, or antipsychotics.
- You are not already doing structured aerobic or resistance exercise 3 or more times per week.
- You are able to participate in a supervised exercise program and have no medical conditions that make exercise unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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