Duloxetine and Exercise for Knee Arthritis in Veterans
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether a combination of an antidepressant medication (duloxetine) and supervised aerobic exercise can improve knee pain, function, and mood in veterans with knee osteoarthritis who also have depression symptoms. The goal is to help you move better and feel better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a veteran aged 40 or older
- You have knee osteoarthritis (wear-and-tear arthritis in the knee) with pain
- You have mild to severe depression symptoms (measured by a screening questionnaire)
- You are not currently taking antidepressants, opioid painkillers, anti-anxiety medications, or antipsychotic medications
- You can participate in supervised aerobic exercise (like walking, cycling, or using a treadmill) at the study site
- You are not planning to have knee surgery in the next 6 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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