Doxycycline for brain tuberculosis
Treatments studied
Part of Brain & nervous system, Infections clinical trials.
This trial tests whether adding the antibiotic doxycycline to standard treatment can improve recovery in patients with tuberculosis of the brain (TB meningitis). It may help reduce brain swelling and damage.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 21 years old or older.
- You have started TB treatment within the last 7 days or are about to start.
- You have been diagnosed with TB meningitis (definite, probable, or possible).
- Your liver function (ALT) is less than 3 times the normal upper limit.
- You are not pregnant or breastfeeding and have no active cancer or autoimmune disease on immune-suppressing drugs.
- You are not allergic to tetracycline antibiotics (like doxycycline).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a shorter, more intensive treatment for tuberculosis that affects the brain. It may help reduce side effects while still curing the infection.
This Phase 3 trial tests whether adding doxycycline to standard TB medicine can improve lung function and reduce lung tissue damage. It aims to see if patients recover better by targeting the lung response to TB.
This trial tests if giving a stronger combination of TB drugs for meningitis can save more lives. It's for patients who have been diagnosed with tuberculosis meningitis and have not yet started more than 5 days of TB treatment.
This trial tests whether the antibiotic doxycycline can prevent lung scarring (fibrosis) after a serious TB infection. You may be eligible if you are currently being treated for active TB and have significant lung damage on your chest X-ray.
This trial tests a new antibiotic called contezolid for people with tuberculous meningitis, an infection of the brain lining. The goal is to see if it works well and is safe.
This trial looks at whether continuing treatment for a bacterial brain abscess using partially oral antibiotics works as well as the usual approach. It may help people who have already had 14 days of antibiotic treatment and are stable enough to take medicines by mouth.
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