Stronger TB treatment for meningitis to reduce deaths
Treatments studied
Part of Brain & nervous system, Infections clinical trials.
This trial tests if giving a stronger combination of TB drugs for meningitis can save more lives. It's for patients who have been diagnosed with tuberculosis meningitis and have not yet started more than 5 days of TB treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 15 years or older.
- You have been diagnosed with tuberculosis meningitis (definite, probable, or possible).
- You have not taken TB treatment for more than 5 days.
- You do not have severe kidney, liver, or blood problems.
- You are not pregnant beyond 17 weeks or breastfeeding.
- You do not have drug-resistant TB or certain other infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a shorter, more intensive treatment for tuberculosis that affects the brain. It may help reduce side effects while still curing the infection.
This Phase 2 trial studies whether a TNF-blocking medicine can lower the risk of death in people with HIV who also have TB meningitis. You would receive standard TB meningitis treatment plus the study drug, if you meet the criteria.
This Phase 2 study tests whether a shorter, stronger 6-month set of medicines works as well as the usual 9-month regimen for tuberculous meningitis (TB infection in the covering of the brain/spinal cord). The goal is to improve outcomes while reducing treatment time and exposure.
This trial tests a combination of TB medicines (B-PaLMZ) for people with HIV who have their first episode of TB meningitis. It aims to find a better treatment option.
This study tests a new combination of two antibiotics (alpibectir and ethionamide) for people with tuberculosis meningitis. The goal is to see if this combination is safe and works well against the infection.
This trial tests whether adding the antibiotic doxycycline to standard treatment can improve recovery in patients with tuberculosis of the brain (TB meningitis). It may help reduce brain swelling and damage.
Hear when a new Tuberculous Meningitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.