Testing safety and effectiveness of LAmbre Plus device for AFib
Part of Heart & circulation clinical trials.
This trial tests a new device (LAmbre Plus) that closes off a small pouch in the heart (left atrial appendage) to reduce stroke risk in people with AFib who cannot take blood thinners long-term. The procedure is an alternative to daily medication.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older and not pregnant or nursing.
- You must have a type of atrial fibrillation (AFib) that is not caused by a short-term issue like surgery or infection.
- You must have a moderate to high risk of stroke, as measured by a CHADS2 or CHA2DS2-VASc score.
- Your doctor must agree that a short course of blood thinner (warfarin) is safe for you, but a non-medication approach is better long-term.
- Your heart team (including a cardiologist) must decide together that this procedure is right for you.
- You must not have certain heart valve problems, recent stroke or heart attack, or other major health issues that would make the procedure unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is testing a device called LAMBRE that is used to close a small pocket in the heart (the left atrial appendage). The goal is to see how well it works in everyday medical practice for people who need this closure procedure.
This trial tests a new device called ENDOMATIC SEPIOLA that closes a small pouch in your heart (the left atrial appendage) to lower your stroke risk. It is a non-surgical option for people with atrial fibrillation who cannot take blood thinners.
This study tests whether it is safe and effective to use just one blood thinner (aspirin or clopidogrel) for a short time after getting a LAmbre device implanted to close off a heart pouch that can cause strokes. It is for people with atrial fibrillation who cannot take standard blood thinners long-term.
This trial compares a heart device that can help prevent blood clots in the heart (called LAAO) versus long-term blood thinners for people who have atrial fibrillation and recently had a stent placed. It aims to see which approach better prevents stroke and related blood-clot problems while keeping side effects manageable.
This trial tests a left atrial appendage closure device for people with atrial fibrillation who need an alternative to long-term blood thinners. It aims to see if the procedure can be done safely with conscious sedation instead of general anesthesia.
This trial combines two procedures at once: a pulsed field ablation to treat atrial fibrillation and a device implant to close the left atrial appendage to reduce stroke risk. It is designed for people in Asia who need both treatments and may benefit from having them together.
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