Testing a new device to close the left atrial appendage in AFib
Part of Heart & circulation clinical trials.
This trial tests a new device called ENDOMATIC SEPIOLA that closes a small pouch in your heart (the left atrial appendage) to lower your stroke risk. It is a non-surgical option for people with atrial fibrillation who cannot take blood thinners.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have atrial fibrillation (AFib) that is not caused by a heart valve problem.
- Your doctor has calculated your stroke risk score (CHA2DS2-VASc) to be 2 or higher.
- You cannot take blood thinners, or you have a reason to avoid them (like side effects or bleeding risk).
- Your heart's left atrial appendage (a small pouch in your heart) must have the right shape and size for the device – your doctor will check this.
- You do not have other severe heart conditions, such as a prosthetic valve, a hole in your heart that's been closed, severe mitral stenosis, or a specific stent in your heart artery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests the Zenith system, a device that seals off a heart area called the left atrial appendage to reduce stroke risk in people with atrial fibrillation (AF). You may be eligible if you have AF and a doctor recommends LAA closure, and you can return for follow-up scans and visits.
This study tests a procedure that seals off the left atrial appendage (a small heart pouch) to help prevent stroke in people with atrial fibrillation. You may be considered if your stroke risk is high and you are already on blood-thinner medicine.
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This trial compares a simpler procedure to the standard one for closing the left atrial appendage in people with non-valvular atrial fibrillation. The goal is to see which approach works better for preventing strokes while lowering bleeding risks.
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