Maintenance therapy after stem cell transplant for CD123-positive AML/MDS
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a combination of two drugs, tagraxofusp and azacitidine, given as maintenance therapy after a stem cell transplant. The goal is to prevent the leukemia or MDS from coming back in patients whose cancer cells carry a specific marker called CD123.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have AML or MDS with high-risk features and have had a stem cell transplant (donor) within the last few months.
- Your leukemia or MDS cells tested positive for CD123 (a protein) before your transplant.
- After transplant, your disease is in remission or has only a small amount of leftover disease.
- Your blood counts (neutrophils and platelets) are recovering well and you are not on high doses of steroids for graft-versus-host disease (GVHD).
- You are between 18 and 75 years old and have a good overall health status (ECOG score 0-2, meaning you can care for yourself).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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