Clin2
NCT06499233Likely a fitRecruiting

Study on preventing pneumocystis pneumonia in autoimmune disease

Pneumonia, PneumocystisAutoimmune Inflammatory Rheumatic DiseaseAutoimmune DiseasesConnective Tissue DiseasePrevention

Treatments studied

Part of Immune system & allergy, Infections, Lungs & breathing, Skin clinical trials.

This trial tests whether a preventive treatment can stop pneumocystis pneumonia (a lung infection) in people with autoimmune inflammatory rheumatic diseases who are taking steroids or other immune-suppressing medicines. It aims to find the safest and most effective way to protect you from this serious infection.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
800 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have an autoimmune inflammatory rheumatic disease (like lupus, rheumatoid arthritis, or similar).
  • You are currently taking steroids or other medicines that suppress your immune system.
  • You are 18 years old or older.
  • You have not yet received the standard preventive treatment (TMP/SMZ) for pneumocystis pneumonia.
  • You do not have severe liver, kidney, or blood problems, and you do not have HIV, cancer, or an organ transplant.
  • You are not pregnant, breastfeeding, or allergic to sulfa drugs.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04851015Recruiting· Phase 3
Low-dose TMP-SMX for Pneumocystis pneumonia (PCP)

This Phase 3 study tests whether low-dose trimethoprim-sulfamethoxazole (also called TMP-SMX) can treat Pneumocystis pneumonia (PCP) in people with weakened immune systems. It may help improve treatment while reducing side effects compared with standard dosing.

Montreal, Quebec
NCT07231770Recruiting
Sulfamethoxazole prevention study after kidney transplant

This trial tests how long kidney transplant patients should take a common antibiotic (sulfamethoxazole) to prevent a lung infection called PJP. You may join if you are between 18 and 70 and have had a kidney transplant.

Hefei, Anhui
NCT07152613Not yet recruiting· Phase 3
Steroids for severe Pneumocystis pneumonia in ICU patients

This trial tests whether giving steroids (anti-inflammatory medicines) to people with a severe lung infection called Pneumocystis pneumonia (PJP) can improve outcomes. It is for patients who are in the ICU and do not have HIV, which is a different group than typical PJP patients.

NCT07357103Not yet recruiting· Phase 4
Second-line treatments for pneumocystis pneumonia in immunocompromised patients

This study compares different second-line antibiotics for treating Pneumocystis pneumonia (a serious lung infection) in people with weakened immune systems. It aims to find the best alternative when the standard treatment cannot be used.

NCT07242092Recruiting· Phase 4
Pausing methotrexate to boost pneumonia vaccine response

This study tests whether stopping methotrexate for a short time before getting the pneumonia vaccine (PCV20) helps your body build a stronger immune response. It is for people with autoimmune rheumatic diseases like rheumatoid arthritis or lupus whose disease is under control.

São Paulo, São Paulo
NCT07665359Not yet recruiting
Antibiotic treatment to reduce COPD flare-ups

This trial tests whether giving a special antibiotic treatment to clear a common lung fungus (Pneumocystis jirovecii) can reduce how often COPD flare-ups happen. If you qualify, this might help you have fewer severe episodes.

Guangzhou, Guangdong

Hear when a new Autoimmune Diseases trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.