Genistein for heart failure inflammation
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests a natural substance called genistein (found in soy) to reduce inflammation in people with heart failure. It may help your heart work better and feel better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have heart failure with or without a specific cause, and your heart pumps less than 40% of the blood out with each beat (or you have a certain type of heart muscle disease called ATTR amyloidosis).
- Your heart medications have been stable for at least 1 month, and you've been on the optimal doses for 3 months.
- A blood test shows your NT-proBNP (a protein that rises when the heart is stressed) is above 350 pg/mL.
- You are not on a vegan diet, and you do not take isoflavone or resveratrol supplements.
- You do not have serious liver, kidney, or blood problems, uncontrolled diabetes, a recent infection, or a history of alcohol abuse.
- You are not pregnant, you have no active cancer, and you haven't had a heart procedure in the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether adding selenium and CoQ10 (two natural supplements) to standard heart failure treatment helps people with chronic heart failure feel better and improve their health. Researchers are using a registry-based approach to track participants in the Netherlands.
This trial tests whether a low-dose colchicine (LoDoCo) can help people with heart failure and inflammation feel better and exercise more. It is for adults 50 and older with HFpEF who have signs of inflammation in their blood.
This trial tests whether adding L-arginine, a natural amino acid, to your usual heart failure treatment can help your heart pump better. It is for people with moderate to severe heart failure and stable kidney function.
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