Ketamine plus venlafaxine for severe depression
Treatments studied
Part of Mental health clinical trials.
This trial tests whether adding ketamine to the antidepressant venlafaxine helps relieve severe depression faster than venlafaxine alone. If you are hospitalized for a serious depression and you meet safety criteria, you may be eligible.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are currently hospitalized for a severe episode of depression (score of 24 or higher on a depression rating scale).
- Your doctor plans to start you on the antidepressant venlafaxine.
- You must not have tried two or more different antidepressants that failed in the past (for this episode).
- You have no history of bipolar disorder, schizophrenia, or a psychotic depression.
- You are not pregnant or breastfeeding, and if you could become pregnant, you agree to use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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