Understanding blood vessel problems in people with angina
Part of Heart & circulation clinical trials.
This study looks at why some people with angina (chest pain) have problems with the tiny blood vessels in the heart, even when the large arteries are not blocked. It aims to understand the cause, which may help improve future treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have angina and a test showing reduced blood flow reserve in the heart (microvascular dysfunction).
- If you are a woman of childbearing age, you must be postmenopausal (no periods for at least a year) or surgically sterile.
- You do not have heart failure (ejection fraction below 40%).
- Your blood pressure is controlled (not above 140/90).
- You are not already very physically active (maximal oxygen uptake not above 45 ml/kg/min).
- You have no allergy to norepinephrine, adenosine, ketorolac, or vitamin C.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial looks at how to assess small blood-vessel (microvascular) problems in people who had a heart attack but whose main heart arteries are not blocked. It may help doctors better find what’s driving symptoms and choose the right tests and treatments.
This trial tests if exercise training can help people who have chest pain or shortness of breath even though their main heart arteries are not blocked. It focuses on those with small vessel disease in the heart, also known as INOCA.
This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.
This trial is testing a new way to diagnose problems in the small blood vessels of the heart that can cause chest pain even when the main arteries look clear. The test uses a special technique to measure how well these small vessels work, which could help find the cause of your symptoms.
This study looks at the tiny blood vessels in your heart (the microcirculation) that can cause chest pain even when the main arteries are open. It aims to better understand and treat this type of chest pain, called chronic coronary syndrome.
This study looks at why some people have chest pain or other heart symptoms even when their main heart arteries are not blocked. It tests whether inflammation in the small blood vessels of the heart might cause these symptoms, and aims to understand how to better diagnose and treat this condition.
Hear when a new Coronary Microvascular Dysfunction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.