Early antiplatelet after clot-busting for stroke (TREND-IVT)
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether giving an antiplatelet medicine (like aspirin) early—within 3 hours of a clot-busting drug—can help prevent another stroke without causing bleeding. It is for people who still have moderate to severe stroke symptoms after the clot-buster and do not have a large artery blockage.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You had a stroke and received a clot-busting medicine (alteplase or tenecteplase) within 4.5 hours of symptoms starting.
- One hour after the clot-buster, your stroke symptoms are still moderate to severe (NIHSS score >5).
- You do not have a large artery blockage needing a separate clot removal procedure.
- You have not taken antiplatelet medicine (like aspirin or clopidogrel) in the week before your stroke.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests whether guiding antiplatelet medication with a blood test can help prevent another stroke or TIA. It looks at people who have had a mild stroke or high-risk TIA within the last 48 hours.
This trial tests whether taking a low dose of aspirin soon after a stroke, when clot-busting medication has already been given, is safe and helps improve recovery. It may help prevent another stroke and is designed for people whose strokes are caused by blocked blood vessels in the brain.
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This study tests whether a clot-busting medicine given through a vein can help people who have had a stroke in the last 3 months and are now having another stroke. The goal is to see if this treatment is safe and improves recovery.
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