Tenecteplase for Recent Stroke Using Special Brain MRI Patterns
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether tenecteplase (a clot-busting medication) can help patients who have had a stroke within 4.5 to 9 hours and show a specific pattern on brain MRI called DWI-FLAIR mismatch, which suggests the brain tissue may still be salvageable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18 or older
- Stroke symptoms started between 4.5 and 9 hours before hospital arrival (includes strokes noticed upon waking or unwitnessed strokes)
- Brain MRI shows a specific pattern: visible damage on DWI scan but no marked damage on FLAIR scan
- Stroke damage is small to moderate (not covering more than one-third to one-half of major brain artery territories)
- Neurological symptoms score between 4 and 25 on the NIHSS scale (measures stroke severity)
- This is your first stroke, or you had a previous stroke but recovered well (pre-stroke disability score 0–1)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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