Selinexor plus ICE chemo for brain-involved B-cell lymphoma
Treatments studied
Part of Blood & lymphatic, Brain & nervous system, Cancer clinical trials.
This trial tests a new drug, selinexor, combined with standard ICE chemotherapy for patients whose B-cell non-Hodgkin lymphoma has spread to the brain or spinal cord. It aims to see if adding selinexor improves treatment results.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of B-cell non-Hodgkin lymphoma that has spread to the brain or spinal cord.
- You have had at least one round of standard chemotherapy with a drug called anthracycline.
- You are 18 years old or older.
- You have at least one tumor that is 1.5 cm or larger that can be measured on scans.
- You are in fairly good health (ECOG score 0–2, meaning you can do most daily activities).
- Your blood counts and kidney/liver function are within acceptable ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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