Surgery and reduced radiation for neck cancer of unknown origin
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This study tests whether giving less radiation after surgery is as effective as standard radiation for people with a specific type of neck cancer that started somewhere unknown. It aims to reduce side effects while keeping the cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a type of neck cancer called p16-positive squamous cell carcinoma, which is often linked to HPV.
- Your cancer is only on one side of your neck, and the largest lymph node is 6 cm or smaller.
- You have had a complete work-up, including a CT scan, a physical exam with a scope, and a PET/CT scan, and no primary tumor was found.
- You are willing to have a tonsillectomy and a biopsy of the base of your tongue to confirm no primary tumor is there.
- You have not had head or neck cancer in the last 2 years, and you do not have any other active cancer except for certain skin, prostate, or thyroid cancers.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving lower doses of radiation to certain parts of the throat can be just as effective as standard doses, while reducing side effects. It is for people with HPV-positive throat cancer, which tends to respond well to treatment.
This trial looks at whether giving less (de-escalated) radiation after surgery is as effective and safer for people with locally advanced head and neck squamous cell carcinoma who had a strong response to treatment before surgery. If you had no remaining cancer or only very small amounts of cancer left in the surgical specimen, this approach may help reduce side effects while keeping control of the disease.
This trial tests a lower dose of radiation to certain neck areas for people with HPV-related oropharyngeal cancer. The goal is to see if reducing radiation can cause fewer side effects while still curing the cancer.
This trial tests whether patients with early-stage oral cancer who have surgery and lymph-node removal can skip radiation to the neck if certain favorable conditions are met. The goal is to reduce side effects like difficulty swallowing while keeping cancer control strong.
This trial studies a lower-intensity (less aggressive) course of radiation therapy after curative surgery for HPV-related tonsil or base-of-tongue cancer. The goal is to see if patients can still be treated successfully while reducing side effects from radiation.
This trial tests a new way of giving radiation therapy only to the side of the neck that needs it, which may reduce side effects while still preventing cancer from coming back. It is for people who have had surgery for head and neck cancer and have not had the cancer spread to the lymph nodes.
Hear when a new Head and Neck Squamous Cell Carcinoma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.