Trametinib for Langerhans cell histiocytosis (LCH)
Treatments studied
Part of Blood & lymphatic, Lungs & breathing clinical trials.
This trial tests a targeted drug called trametinib (a MEK inhibitor) for people with Langerhans cell histiocytosis (LCH) that is newly diagnosed, relapsed, or hasn't responded to other treatments. It aims to see if trametinib can better control the disease with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with LCH (new, relapsed, or not responding to other treatments) or have been taking trametinib for LCH since January 2020.
- Your LCH diagnosis was confirmed by a biopsy before starting treatment.
- Your heart function is good (checked by an echo or EKG within the last month).
- Your blood counts (like white cells, platelets, and hemoglobin) are in a safe range.
- You do not have a certain rare genetic change (class 3 MAP2K1 mutation) that would make trametinib less likely to work.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new targeted drug called luvometinib, either alone or with a standard chemotherapy drug (cytarabine), for people with Langerhans cell histiocytosis. The goal is to see if adjusting the treatment based on your response can help control the disease.
This Phase 2 trial studies cobimetinib, a medicine that targets a specific growth-and-signal pathway, to treat stubborn (refractory or worsening) Langerhans cell histiocytosis and related disorders. It may help shrink active disease or stop disease from progressing.
This trial tests a study drug, FCN-159, for children with a rare blood/immune disease called Langerhans cell histiocytosis (LCH) that has not responded to standard treatment or has come back. The goal is to see if this drug can shrink the LCH lesions and help the child feel better.
This trial tests a combination of two drugs, low-dose cytarabine and thalidomide, for adults with Langerhans cell histiocytosis (LCH) that has not been treated before with systemic therapy. The goal is to see if this treatment is safe and effective for people with LCH in multiple body areas or multiple spots in one system.
This Phase 3 trial tests a treatment plan that includes cytarabine for children newly diagnosed with LCH (a rare condition where abnormal immune-related cells form lesions). It may help control the disease while comparing outcomes with a cytarabine-based protocol.
This trial tests a combination of two drugs for children and teens with Langerhans cell histiocytosis (LCH) that has not responded to standard treatments or has come back after treatment. The goal is to see if the drugs can shrink lesions and improve symptoms.
Hear when a new Langerhans Cell Histiocytosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.