Adebrelimab and trametinib for children with hard-to-treat LCH
Part of Blood & lymphatic, Lungs & breathing clinical trials.
This trial tests a combination of two drugs for children and teens with Langerhans cell histiocytosis (LCH) that has not responded to standard treatments or has come back after treatment. The goal is to see if the drugs can shrink lesions and improve symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosis of LCH confirmed by biopsy with specific markers.
- Age between 1 and 17 years old.
- LCH is refractory (not responding) or recurrent (came back after treatment).
- Good general health (ECOG score 0-1 or Lansky/Karnofsky score at least 50%).
- Adequate organ function (heart, kidney, liver, bone marrow, and oxygen levels).
- Signed consent from patient or legal guardian.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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