Psilocybin with or without pimavanserin pretreatment
Treatments studied
Part of Mental health clinical trials.
This trial tests whether taking pimavanserin before psilocybin changes the drug's effects in healthy volunteers who have never used psychedelics. It aims to understand how to make psychedelic therapy safer and more predictable.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Aged 21 to 65 years old
- Right-handed
- No past use of psychedelic drugs like psilocybin, LSD, MDMA, or ketamine
- No current or past psychiatric conditions (like depression, bipolar, or substance use disorder)
- Not currently taking antidepressants, antipsychotics, or other neuropsychiatric medications
- No first-degree relative with schizophrenia, bipolar I, or other psychotic disorders
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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