HS-20106 for anemia in low-risk myelodysplastic syndromes
Part of Blood & lymphatic clinical trials.
This trial tests an experimental drug, HS-20106, to see if it can improve low red blood cell counts (anemia) for people with a certain type of bone marrow disorder called myelodysplastic syndromes (MDS), which is not high risk. It might be an option if you have not received certain prior treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a diagnosis of myelodysplastic syndrome (MDS) that is considered very low, low, or intermediate risk.
- Your bone marrow has less than 5% blast cells and your blood has less than 1% blast cells.
- You have low hemoglobin (60 to 100 grams per liter) and meet specific transfusion needs based on your group: no recent transfusions, low transfusion need, or high transfusion need.
- You must be well enough to perform daily activities (ECOG score of 0, 1, or 2) and if the fatigue is related to anemia.
- You cannot have been treated with certain drugs (like azacitidine, decitabine, lenalidomide, luspatercept, or sotatercept) before.
- You must not be pregnant or breastfeeding, and if you can have children, you must use effective birth control.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an investigational drug called TAK-226 for Japanese patients with a type of bone marrow disorder called lower-risk myelodysplastic syndromes (MDS) who have anemia. It aims to see if the drug can help reduce the need for red blood cell transfusions or improve symptoms like fatigue.
This trial tests an experimental drug called AND017 for people with a certain type of myelodysplastic syndrome (MDS) that is low-risk and not linked to a chromosome 5 deletion. The goal is to see if AND017 can help improve low red blood cell counts (anemia) and reduce or avoid the need for blood transfusions.
This trial tests an investigational drug called elritercept for adults with a specific type of low-risk MDS (myelodysplastic syndromes) who have anemia (low red blood cells) and need regular blood transfusions. The goal is to see if elritercept can reduce or eliminate the need for transfusions.
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