Study of high-dose methotrexate, thiotepa, and zanubrutinib for new PCNSL
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of three drugs (high-dose methotrexate, thiotepa, and zanubrutinib) for people who have just been diagnosed with primary central nervous system lymphoma (PCNSL). The goal is to see if this three-drug cocktail works better than standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have a confirmed diagnosis of primary central nervous system lymphoma (PCNSL).
- You have at least one measurable tumor in the brain or spine seen on an MRI or CT scan.
- Your blood counts and organ function (kidney, liver, pancreas) are within acceptable ranges.
- You are able to have MRI/CT scans and a lumbar puncture (spinal tap) as part of the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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