Lemborexant to prevent confusion after heart surgery
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This trial tests if lemborexant, a sleep medication, can help prevent confusion (delirium) after open-heart surgery. If you are having heart surgery through a chest incision, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are admitted to the hospital after open-heart surgery through the middle of your chest.
- You do not have severe sleep apnea (a condition where breathing stops during sleep) or related sleep disorders.
- You are not currently struggling with alcohol or drug misuse.
- You are not taking certain medications that affect the study drug.
- You do not have severe liver or kidney problems, or a very high body mass index (BMI > 40).
- You are able to communicate in English.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests if the sleep medication lemborexant can help people with opioid use disorder who also have chronic insomnia. Participants must already be taking buprenorphine (Suboxone) for at least 4 weeks. The goal is to see if better sleep improves mood and reduces opioid use.
This trial tests whether a newer sedative (remimazolam) or a commonly used one (dexmedetomidine) is better at preventing delirium after planned heart surgery that requires a heart-lung machine. If you are having elective coronary bypass or valve surgery, you may be able to join.
This study tests whether a combination of sleep therapy, brain games, and light exercise before heart surgery can help prevent confusion or disorientation (delirium) after the operation. Participants will be asked to use a tablet and fitness tracker daily for about an hour before their surgery.
This trial tests if lemborexant can help older adults recover their thinking abilities after experiencing confusion following surgery. It compares lemborexant to a placebo to see if it improves cognitive function.
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